3-Aminopropionitrile → 3-(Di-5-hexenyl)aminopropionitrile

HRID 18382

反応式

HRID 18382 の反応式
[NH2:1][CH2:2][CH2:3][C:4]#[N:5].Br[CH2:7][CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12].[I-].[Na+].C(=O)([O-])[O-].[K+].[K+]>C(OCC)C.CN(C)C=O>[CH2:7]([N:5]([CH2:12][CH2:11][CH2:10][CH2:9][CH:8]=[CH2:7])[CH2:4][CH2:3][C:2]#[N:1])[CH2:8][CH2:9][CH2:10][CH:11]=[CH2:12]

参加物

7

反応物 4

HCID 16473-AminopropionitrileHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 759066-Bromo-1-hexene

生成物 1

HCID 121366273-(Di-5-hexenyl)aminopropionitrile収率 67%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6228Dimethylformamide溶媒

実験手順

N,N-Dimethylformamide (28 ml) was added to 3-aminopropionitrile (0.98 g, 14 mmol), and the mixture was stirred at room temperature. 6-Bromo-1-hexene (5.0 g, 31 mmol), sodium iodide (11 g, 73 mmol) and potassium carbonate (5.8 g, 42 mmol) were added to the mixture, and the whole was stirred overnight. The reaction mixture was diluted with diethyl ether (100 ml), and the whole was washed with water (100 ml, twice) and saturated brine (50 ml) successively. The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography to give 3-(di-5-hexenyl)aminopropionitrile (2.2 g, 66%) as a colorless oily matter.

後処理

  1. stirringthe whole was stirred overnight
  2. washthe whole was washed with water (100 ml
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting residue was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-ac0a6b6c606f4b0f9a11ff9d59f587bb
出典データセット
uspto-grants-2010_06
特許番号
US07741346B2

関連ノート

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