Hydroxylamine HCl → 1,5,6,7-Tetrahydro-indol-4-one oxime

HRID 1839656

反応式

HRID 1839656 の反応式
[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=O)[C:4]=2[CH:3]=[CH:2]1.[Cl-].[OH:12][NH3+:13]>N1C=CC=CC=1>[NH:1]1[C:9]2[CH2:8][CH2:7][CH2:6][C:5](=[N:13][OH:12])[C:4]=2[CH:3]=[CH:2]1

参加物

4

反応物 2

HCID 21645Hydroxylamine HClHCID 2802291,5,6,7-Tetrahydro-4H-indol-4-one

生成物 1

HCID 9156771,5,6,7-Tetrahydro-indol-4-one oxime

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

To a stirred solution of 1,5,6,7-tetrahydro-indol-4-one (5.4 g) in pyridine (40 mL) was added hydroxyammonium chloride (2 eq.) at rt. After 2 hours, the solvent was removed and the residue was diluted with water and extracted with ethyl acetate. The combined extracts were washed with brine, dried and concentrated to give 5.5 g of 1,5,6,7-tetrahydro-indol-4-one oxime as a pale yellow solid.

後処理

  1. customthe solvent was removed
  2. additionthe residue was diluted with water
  3. extractionextracted with ethyl acetate
  4. washThe combined extracts were washed with brine
  5. customdried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-1f4182a0e19c4b4f8f6ed3732832b648
出典データセット
uspto-grants-2004_01
特許番号
US06677368B2

関連ノート

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