Trifluoroacetic acid → 2-(4-Methylbenzyl)phenol

HRID 1840715ノート

反応式

HRID 1840715 の反応式
[CH3:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6](O)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[OH:13])=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>CO.[Pd]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[OH:13])=[CH:15][CH:16]=1

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 2751544Cresyl saligenin

生成物 1

HCID 36460202-(4-Methylbenzyl)phenol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of crude Part A 4-methyl-2′-hydroxybenzhydrol (9.7 g containing no more than 40 mmol) in 175 mL of MeOH was added 0.59 g of 10% Pd/C and 1.75 mL of TFA. The suspension was stirred for 40 hr under 1 atmos. H2, filtered through celite and concentrated to yield 8.6 of crude 2-(4′-methylbenzyl)phenol as an oil.

後処理

  1. filtrationH2, filtered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-e2df7b3e911e4dd7a086b3f53bef24c9
出典データセット
uspto-grants-2004_01
特許番号
US06683056B2

反応ノート

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