Chlorotrimethylsilane → 2-(3-Chloro-4-fluorophenyl)ethan-1-amine

HRID 1843908ノート

反応式

HRID 1843908 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]=[CH:9][N+:10]([O-])=O)[CH:5]=[CH:4][C:3]=1[F:13].[BH4-].[Li+].C[Si](Cl)(C)C>C1COCC1>[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][NH2:10])[CH:5]=[CH:4][C:3]=1[F:13]

参加物

5

反応物 3

HCID 6397ChlorotrimethylsilaneHCID 4148881Lithium borohydrideHCID 668018422-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene

生成物 1

HCID 224638772-(3-Chloro-4-fluorophenyl)ethan-1-amine収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Using the same reaction procedure and workup as described in Example 33, 2-Chloro-1-fluoro-4-(2-nitro-vinyl)-benzene (I-34a: 1.7 g, 8.4577 mmol) in dry THF (17 mL) was reacted with lithium borohydride (736.8 mg, 33.8308 mmol) and trimethylsilyl chloride (8.6 mL, 67.6616 mmol) in dry THF (9 mL) to afford 1.3 g of the product (100% yield).

後処理

  1. customthe same reaction procedure

出典と根拠

ORDレコード
ord-217d9d13efc2488bb7b72be65b102e38
出典データセット
uspto-grants-2015_02
特許番号
US08946260B2

反応ノート

読み込み中…