Chlorotrimethylsilane → HCID 55254012、化合物

HRID 1843938ノート

反応式

HRID 1843938 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH:10]=[CH:11][N+:12]([O-])=O.Cl[Si](C)(C)C.[Li+].[BH4-]>C1COCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][C:3]=1[CH2:10][CH2:11][NH2:12]

参加物

5

反応物 3

HCID 6397ChlorotrimethylsilaneHCID 4148881Lithium borohydrideHCID 66692011HCID 66692011、化合物

生成物 1

HCID 55254012HCID 55254012、化合物収率 101%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1-Fluoro-4-methoxy-2-(2-nitro-vinyl)-benzene (3 g, 15.22 mmol) was reacted with chlorotrimethylsilane (13.2 g, 121.51 mmol) and LiBH4 (1.32 g, 60.91 mmol) in dry THF (50 mL) at 0° C. The resulting mixture was stirred for 72 hours at room temperature to afford 2.6 g of the crude product which was used in the next step without further purification.

出典と根拠

ORDレコード
ord-b09fab430592431a84efed205992e08e
出典データセット
uspto-grants-2015_02
特許番号
US08946260B2

反応ノート

読み込み中…