Methyl iodide → Cyclohexyl(1-methyl-1H-pyrrol-2-yl)methanone
反応式
[CH:1]1([C:7]([C:9]2[NH:10][CH:11]=[CH:12][CH:13]=2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[CH3:16]I>CN(C=O)C>[CH:1]1([C:7]([C:9]2[N:10]([CH3:16])[CH:11]=[CH:12][CH:13]=2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1参加物
5
実験手順
Compound 25a (2.0 g, 11.3 mmol dissolved dry DMF) was added portionwise to the mixture of NaH (60%; 0.904 g, 22.6 mmol) and dry DMF (200 mL) and the mixture was stirred for 30 min at rt, then MeI (1.9 g, 11.6 mmol) was added at 0° C. The stirred mixture was allowed to stand at rt for 2 h, poured slowly into ice-water and extracted with EA. The organic phase was dried (MgSO4), evaporated and purified by CC to give compound 25b (1.73 g, 80%).
後処理
- waitto stand at rt for 2 h
- extractionextracted with EA
- dry with materialThe organic phase was dried (MgSO4)
- customevaporated
- custompurified by CC
出典と根拠
- ORDレコード
- ord-9d8b94d06ea343abb998c87073ac973e
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946446B2
反応ノート
読み込み中…