Sodium hydride → HCID 58409919、化合物

HRID 1844884ノート

反応式

HRID 1844884 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1O[C:15](=O)[C:14]([C:18]#[N:19])=[C:13]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH:12]=1.[H-].[Na+]>C1COCC1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[C:11]1[C:9]2[C:10]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[CH2:6][C:15]=2[C:14]([C:18]#[N:19])=[C:13]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH:12]=1

参加物

4

反応物 2

HCID 24758Sodium hydrideHCID 110888242H-Pyran-3-carbonitrile, 6-(2-naphthalenyl)-2-oxo-4-(1-piperidinyl)-

生成物 1

HCID 58409919HCID 58409919、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 6-(naphthalen-2-yl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carbonitrile (330 mg), indanone-2 (132 mg) and NaH (43 mg) in THF was stirred for <5 min. After completion, the reaction solvent was evaporated under vacuum to dryness and crude solid was quenched with ice water and subsequently neutralized with dil. HCl, finally purified by column chromatography using ethylacetate-hexane as eluent. White solid; mp 142-144° C.; ESIMS 401 (M++1); IR (KBr) 2215 cm−1 (CN).

後処理

  1. customAfter completion, the reaction solvent was evaporated under vacuum to dryness
  2. customcrude solid was quenched with ice water
  3. customfinally purified by column chromatography

出典と根拠

ORDレコード
ord-83a15ec41b294bc1ab58eaf8956232b4
出典データセット
uspto-grants-2015_02
特許番号
US08946682B2

反応ノート

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