Sodium borohydride → 1-(4-Chloro-3-(methylsulfonyl)phenyl)ethanol
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[S:11]([CH3:14])(=[O:13])=[O:12].[BH4-].[Na+]>O1CCCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:10])[CH3:9])=[CH:4][C:3]=1[S:11]([CH3:14])(=[O:12])=[O:13]参加物
4
実験手順
A round bottom flask was charged with 1-(4-chloro-3-(methylsulfonyl)phenyl)ethanone (12.0 g, 50.0 mmol) and tetrahydrofuran (100 mL) at 0° C. Sodium borohydride (3.7 g, 100 mmol) was added in portions and the reaction was stirred for 12 h at room temperature. The reaction was quenched with ice and extracted with MTBE. The organic solvents were removed under reduced pressure and the residue was purified by flash chromatography to get the title compound.
後処理
- customThe reaction was quenched with ice
- extractionextracted with MTBE
- customThe organic solvents were removed under reduced pressure
- customthe residue was purified by flash chromatography
出典と根拠
- ORDレコード
- ord-04c9c3ac5a06490b9bbfb2cb5b8cfa06
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08946439B2
反応ノート
読み込み中…