Pyridine → 3-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

HRID 1845204ノート

反応式

HRID 1845204 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]([I:15])[C:8]([CH3:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[NH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.N1C=CC=CC=1>O1CCOCC1>[I:15][C:7]1[C:8]([CH3:14])=[C:9]([CH:13]=[C:5]([S:2]([N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)(=[O:4])=[O:3])[CH:6]=1)[C:10]([OH:12])=[O:11]

参加物

5

反応物 3

HCID 1049PyridineHCID 31268PyrrolidineHCID 581880135-(Chlorosulfonyl)-3-iodo-2-methylbenzoic acid

生成物 1

HCID 581883403-Iodo-2-methyl-5-(pyrrolidin-1-ylsulfonyl)benzoic acid

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A round bottom flask was charged with 5-(chlorosulfonyl)-3-iodo-2-methylbenzoic acid (1.00 g, 2.77 mmol), pyrrolidine (0.278 mL, 3.33 mmol), 1,4-dioxane (4 mL) and pyridine (0.20 mL, 2.5 mmol). The mixture was stirred for 30 minutes. The solvent was removed and the residue was purified by flash chromatography to yield the compound as a yellow solid.

後処理

  1. customThe solvent was removed
  2. customthe residue was purified by flash chromatography

出典と根拠

ORDレコード
ord-21161e9b79f34633964e57838a671d76
出典データセット
uspto-grants-2015_02
特許番号
US08946439B2

反応ノート

読み込み中…