Sodium Hydroxide → HCID 68295126、化合物
反応式
[OH-].[Na+].[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([O:20]C)=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1>CO.C1COCC1>[CH3:3][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]2[CH:15]=[C:14](/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19])[CH:13]=[N:12]2)[CH2:6][CH2:5]1参加物
5
実験手順
An aqueous 3N sodium hydroxide solution (2 mL) was added to a solution of (E)-methyl 3-(1-((1-methylpiperidin-4-yl)methyl)-1H-pyrazol-4-yl)acrylate (220 mg) in MeOH (5 mL) and THF (3 mL) was added aq NaOH (3N, 2 mL) to saponify the methyl ester. Workup was performed as described in Example 12 to generate 209 mg of pure product (0.84 mmol, 100%).
出典と根拠
- ORDレコード
- ord-e689be2c89ab4d73b4894ba3887a652b
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957066B2
反応ノート
読み込み中…