N-bromobutanimide → (3-bromo-6-phenyl-7-{4-{3-[5-(pyridine-2-yl)-1H-[1,2,4]triazole-3-yl)-azetidine-1-ylmethyl]-phenyl}-imidazo[1,2-a]pyrimidin-5-yl)-methylamine
反応式
[CH3:1][NH:2][C:3]1[N:8]2[CH:9]=[CH:10][N:11]=[C:7]2[N:6]=[C:5]([C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]3[CH2:22][CH:21]([C:23]4[N:27]=[C:26]([C:28]5[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=5)[NH:25][N:24]=4)[CH2:20]3)=[CH:14][CH:13]=2)[C:4]=1[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1.[Br:40]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[Br:40][C:9]1[N:8]2[C:3]([NH:2][CH3:1])=[C:4]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[C:5]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][N:19]4[CH2:20][CH:21]([C:23]5[N:27]=[C:26]([C:28]6[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=6)[NH:25][N:24]=5)[CH2:22]4)=[CH:16][CH:17]=3)=[N:6][C:7]2=[N:11][CH:10]=1参加物
4
実験手順
50 mg (0.097 mmol) Methyl-(6-phenyl-7-{4-{3-[5-(pyridine-2-yl)-1H-[1,2,4]triazole-3-yl)-azetidine-1-ylmethyl]-phenyl}-imidazo[1,2-a]pyrimidin-5-yl)-amine are dissolved in 3.9 mL chloroform. 19.1 mg (0.11 mmol) N-bromosuccinimide are added and the reaction mixture is heated for one hour at reflux. The solvent is evaporated and the residue purified by chromatography (silicagel, eluents: dichloromethane/methanol). 15 mg (24.7%) of the desired compound are obtained.