Tetrahydrofuran → HCID 57476168、化合物

HRID 1851425ノート

反応式

HRID 1851425 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]([O:21]CC)=[O:20])=[CH:15]2)(=[O:8])=[O:7].[OH-].[Na+].O1CCCC1>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[S:6]([NH:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]2[C:18]=1[NH:17][C:16]([C:19]([OH:21])=[O:20])=[CH:15]2)(=[O:8])=[O:7]

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 4076385HCID 4076385、化合物

生成物 1

HCID 57476168HCID 57476168、化合物収率 97.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
50 °C

実験手順

A mixture of ethyl 7-[(2-thienylsulfonyl)amino]-1H-indole-2-carboxylate (7.81 g), 8N aqueous sodium hydroxide solution (11.0 mL), tetrahydrofuran (20 mL) and ethanol (30 mL) was stirred at 50° C. overnight. The reaction mixture was concentrated, and water was added to the residue. The mixture was acidified with 10% aqueous citric acid solution, and the resulting crystals were filtrated, washed with water, and dried to give the title compound (7.00 g, yield 97%) as colorless crystals. melting point>268° C. (decomposition).

後処理

  1. concentrationThe reaction mixture was concentrated
  2. additionwater was added to the residue
  3. filtrationthe resulting crystals were filtrated
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-5eabefcee2774c60b223f78641409d8c
出典データセット
uspto-grants-2015_02
特許番号
US08957070B2

反応ノート

読み込み中…