Tetrahydrofuran → HCID 178487751、化合物
反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1.C1C[O:18]CC1>[OH-].[Na+].O>[Cl:1][C:2]1[N:11]=[C:10]([OH:18])[C:9]2[C:4](=[CH:5][C:6]([O:13][CH3:14])=[CH:7][CH:8]=2)[N:3]=1参加物
5
実験手順
2,4-dichloro-7-methoxyquinazoline (500 mg, 2.183 mmol) was suspended in 2% aqueous NaOH (6 mL). THF (1 mL) was added and the reaction was stirred for 4 h. The reaction was diluted with water and the solid that remained was filtered off. The aqueous phase was diluted with 1 N HCl. The precipitate that formed was filtered, washed with water and dried to give 2-chloro-7-methoxyquinazolin-4-ol (288 mg, 63% yield). MS: MS m/z 211.1 (M++1).
後処理
- filtrationthe solid that remained was filtered off
- additionThe aqueous phase was diluted with 1 N HCl
- customThe precipitate that formed
- filtrationwas filtered
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-51fc60faa6634f809e346dcab2e1a2a7
- 出典データセット
- uspto-grants-2015_02
- 特許番号
- US08957203B2
反応ノート
読み込み中…