N-bromobutanimide → 4-Bromo-6-methoxyisoquinolin-1(2H)-one

HRID 1852238ノート

反応式

HRID 1852238 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[NH:8][CH:7]=[CH:6]2.C1C(=O)N([Br:21])C(=O)C1>C(#N)C>[Br:21][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[C:9](=[O:13])[NH:8][CH:7]=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 218898546-methoxyisoquinolin-1(2H)-one

生成物 1

HCID 579564624-Bromo-6-methoxyisoquinolin-1(2H)-one収率 55.2%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 6-methoxyisoquinolin-1(2H)-one (2.5 g, 14.27 mmol) in acetonitrile (10 ml) was added NBS (2.54 g, 14.27 mmol) at room temperature under argon atmosphere. The reaction mass was stirred at the same temperature for 2 h. The precipitated solid was filtered to get crude compound (2 g, 55.2%). The crude compound was taken to the next step without further purification. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.41 (s, 1H), 8.17-8.15 (d, J=8 Hz, 1H), 7.53 (s, 1H), 7.19-7.11 (m, 2H), 3.93 (s, 3H); MS: MS m/z 256.06 (M++2).

後処理

  1. filtrationThe precipitated solid was filtered

出典と根拠

ORDレコード
ord-0dfb9059130f4c95b49aeca4e9f7041c
出典データセット
uspto-grants-2015_02
特許番号
US08957203B2

反応ノート

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