Toluene → Benzimidazole, 2-trichloromethyl-

HRID 18532

反応式

HRID 18532 の反応式
[C:1]1([NH2:8])[C:2]([NH2:7])=[CH:3][CH:4]=[CH:5][CH:6]=1.CO[C:11](=N)[C:12]([Cl:15])([Cl:14])[Cl:13].C1(C)C=CC=CC=1>C(O)(=O)C>[Cl:13][C:12]([Cl:15])([Cl:14])[C:11]1[NH:8][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=2[N:7]=1

参加物

5

反応物 3

HCID 1140TolueneHCID 7243O-PhenylenediamineHCID 100479Methyl 2,2,2-trichloroacetimidate

生成物 1

HCID 77133Benzimidazole, 2-trichloromethyl-

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 10 g Benzene-1,2-diamine in 250 mL acetic acid, 22.8 g 2,2,2-Trichloro-acetimidic acid methyl ester were added drop wise at RT. After 2 h 500 mL toluene were added and the solvents were removed under reduced pressure. The residue was codestilled additional two times with toluene. After drying under reduced pressure the product was pure enough for the next reaction step.

後処理

  1. customthe solvents were removed under reduced pressure
  2. customAfter drying under reduced pressure the product
  3. customwas pure enough for the next reaction step

出典と根拠

ORDレコード
ord-0afa7b3ef23347f6a27ba72298be89b9
出典データセット
uspto-grants-2010_06
特許番号
US07741341B2

関連ノート

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