Methyl iodide → 2-(Methylthio)-5-(pyridin-4-ylmethyl)pyrimidin-4(1H)-one
反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:9](=[O:15])[NH:10][C:11](=[S:14])[NH:12][CH:13]=2)=[CH:3][CH:2]=1.[CH3:16]I.[OH-].[Na+]>O.C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]2[C:9](=[O:15])[NH:10][C:11]([S:14][CH3:16])=[N:12][CH:13]=2)=[CH:3][CH:2]=1参加物
6
実験手順
A solution of 5-(4-pyridylmethyl)-2-thiouracil (11.0 g), methyl iodide (7.2 g) and sodium hydroxide (2.1 g) in water (50 ml) and ethanol (100 ml) was stirred at 60° for 30 minutes, allowed to cool and filtered to give 5-(4-pyridylmethyl)-2-methylthio-4-pyrimidone m.p. 179°-182° (ethanol).
後処理
- temperatureto cool
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-63092aa426514473b17b330ba51d79f6
- 出典データセット
- uspto-grants-1980_08
- 特許番号
- US04216318
反応ノート
読み込み中…