Phosphonic acid → N-methyl-N-(phosphonomethyl)glycine

HRID 1859241ノート

反応式

HRID 1859241 の反応式
[C:1]([N:4]([CH2:6][C:7]([OH:9])=[O:8])[CH3:5])(=O)C.C=O.[OH:12][PH:13]([OH:15])=[O:14].P(Cl)(Cl)Cl>>[P:13]([CH2:1][N:4]([CH3:5])[CH2:6][C:7]([OH:9])=[O:8])([OH:15])([OH:14])=[O:12]

参加物

5

反応物 4

HCID 407Phosphonic acid2 回HCID 712FormaldehydeHCID 24387Phosphorus trichlorideHCID 10975514N-Acetyl-N-methylglycine

生成物 1

HCID 541499N-methyl-N-(phosphonomethyl)glycine

実験手順

As depicted, the carboxymethylation step of Reaction Scheme 12 is the same as the carboxymethylation step of Reaction Schemes 10 and 11. In Reaction Scheme 12, however, N-acetylsarcosine XX is reacted with formaldehyde and H3PO3, PCl3 or other H3PO3 source to produce N-(phosphonomethyl)-N-methyl-glycine XXI which is oxidized in the presence of a platinum catalyst and oxygen to Glyphosate I and acetic acid. The acetic acid is then reacted with methylamine to yield the N-methylacetamide starting material.

後処理

  1. customthe carboxymethylation step of Reaction Scheme 12
  2. customsame as the carboxymethylation step of Reaction Schemes 10 and 11
  3. customIn Reaction Scheme 12

出典と根拠

ORDレコード
ord-c4a8534e865f4f87b8080904090f1e79
出典データセット
uspto-grants-2000_11
特許番号
US06153753

反応ノート

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