Water → (S)-1-(4-dimethylaminophenethyl)-3-hydroxypyrrolidine

HRID 1859451ノート

反応式

HRID 1859451 の反応式
[CH3:1][N:2]([CH3:28])[C:3]1[CH:27]=[CH:26][C:6]([CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([O:14]C(=O)C3C=CC([N+]([O-])=O)=CC=3)[CH2:10]2)=[CH:5][CH:4]=1.O1CCCC1.O.[Li+].[OH-]>CO>[CH3:28][N:2]([CH3:1])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][C@H:11]([OH:14])[CH2:10]2)=[CH:26][CH:27]=1

参加物

6

反応物 4

HCID 962WaterHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 69900132(S)-1-(4-Dimethylaminophenethyl)-3-(4-nitrobenzoyloxy)pyrrolidine

生成物 1

HCID 69900648(S)-1-(4-dimethylaminophenethyl)-3-hydroxypyrrolidine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

(S)-1-(4-dimethylaminophenethyl)-3-(4-nitrobenzoyloxy) pyrrolidine (1.00 g, 2.70 mmol) was dissolved in methanol (20 ml), tetrahydrofuran (20 ml) and water (10 ml). 4M-LiOH (3 ml) was added dropwise in the obtained solution, and they were stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure, and the residue was distributed in water and ether. The organic layer was dried and the solvent was evaporated under reduced pressure to obtain (S)-1-(4-dimethylaminophenethyl)-3-hydroxypyrrolidine in the form of a light yellow solid (320 mg, 62%).

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customThe organic layer was dried
  3. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3e0bbd1f0c324a2d880f4166b09ccf86
出典データセット
uspto-grants-2003_03
特許番号
US06528504B2

反応ノート

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