HCID 10909824、化合物 → 4-Isopropylthiazole-5-carbaldehyde
反応式
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[N:5][C:4]=1[CH:8]([CH3:10])[CH3:9]>C(Cl)(Cl)Cl.O=[Mn]=O>[CH:8]([C:4]1[N:5]=[CH:6][S:7][C:3]=1[CH:2]=[O:1])([CH3:10])[CH3:9]参加物
4
実験手順
A mixture of 4.65 g (30 mmol) of crude 5-(hydroxymethyl)-4-isopropyl-thiazole in 200 mL of chloroform (CHCl3) was treated with 45 g of MnO2 and stirred at room temperature for 2.5 hours. The suspension was filtered, and the filtrate was concentrated. The residue was chromatographed on silica gel, eluting with 3:1 hexane:EtOAc, to give the title compound.
後処理
- filtrationThe suspension was filtered
- concentrationthe filtrate was concentrated
- customThe residue was chromatographed on silica gel
- washeluting with 3:1 hexane
出典と根拠
- ORDレコード
- ord-e936d22f93a842f48aed7144befb05c0
- 出典データセット
- uspto-grants-2003_03
- 特許番号
- US06528510B1
反応ノート
読み込み中…