Sodium hydride → Diethyl 2-(4-benzyloxybenzyl)-2-(4-isopropylphenoxy)malonate

HRID 1859963

反応式

HRID 1859963 の反応式
[CH:1]([C:4]1[CH:21]=[CH:20][C:7]([O:8][CH:9]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[CH2:22]([O:29][C:30]1[CH:37]=[CH:36][C:33]([CH2:34]Cl)=[CH:32][CH:31]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.[H-].[Na+]>>[CH2:22]([O:29][C:30]1[CH:31]=[CH:32][C:33]([CH2:34][C:9]([O:8][C:7]2[CH:20]=[CH:21][C:4]([CH:1]([CH3:2])[CH3:3])=[CH:5][CH:6]=2)([C:10]([O:12][CH2:13][CH3:14])=[O:11])[C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:36][CH:37]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

参加物

4

反応物 3

HCID 24758Sodium hydrideHCID 700424-Benzyloxybenzyl chlorideHCID 10565722Diethyl 2-(4-isopropylphenoxy)malonate

生成物 1

HCID 18625725Diethyl 2-(4-benzyloxybenzyl)-2-(4-isopropylphenoxy)malonate収率 90.1%

実験手順

In a similar manner to that described in Reference example 2(a), a reaction was carried out using diethyl 2-(4-isopropylphenoxy)malonate (21.5 g), which is the product of Reference example 5(a), 4-benzyloxybenzyl chloride (19.7 g) and sodium hydride (55% suspension in oil, 3.53 g) and the reaction mixture was treated to afford the desired compound (32.3 g) as a syrup.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-46561211f63848708c303895625923ff
出典データセット
uspto-grants-2003_03
特許番号
US06528525B1

関連ノート

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