Lithium Hydroxide → Pyrazolo[3,4-d]pyrimidin-4-one
反応式
ClC1C=CC=C(Cl)C=1[N:9]1[C:13]2=[N:14][C:15](CC3C=CC(CC(OCC)=O)=CC=3)=[N:16][C:17](=[O:18])[C:12]2=[C:11](C(C)C)[NH:10]1.C1COCC1.[OH-].[Li+]>O>[N:9]1[C:13]2=[N:14][CH:15]=[N:16][C:17](=[O:18])[C:12]2=[CH:11][N:10]=1参加物
5
実験手順
The ester, 1-(2,6-dichlorophenyl)-3-isopropyl-6-(4-(carbethoxymethyl)benzyl)pyrazolo[3,4-d]pyrimidin-4-one (1.20 g, 2.4 mmol) was stirred at RT overnight with THF (50 mL), water (15 mL) and 1 N lithium hydroxide (7.20 mL). The solution was evaporated to near dryness, diluted with 1 N hydrochloric acid, vigorously stirred and the solid was collected by filtration and dried under high vacuum to give 1-(2,6-dichlorophenyl)-3-isopropyl-6-(4-carboxymethyl)benzyl)pyrazolo[3,4-d]pyrimidin-4-one (1.01 g, 89% yield) as a white solid, mp 212-214° C. Mass Spec.: 471 (M+H)+.
後処理
- customThe solution was evaporated
- additiondiluted with 1 N hydrochloric acid
- filtrationthe solid was collected by filtration
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-49aa2cc2cd034fabab2b8dba755c369d
- 出典データセット
- uspto-grants-2003_03
- 特許番号
- US06531477B1
反応ノート
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