Succinic Acid → HCID 70029953、化合物

HRID 1862062ノート

反応式

HRID 1862062 の反応式
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[C:8]2[C:3]=1[CH2:4][CH2:5][C@@H:6]([NH:19][C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:23][CH:22]=1)[CH2:7]2.[C:34]([OH:41])(=[O:40])[CH2:35][CH2:36][C:37]([OH:39])=[O:38].C(OCC)C>O1CCCC1>[C:34]([OH:41])(=[O:40])[CH2:35][CH2:36][C:37]([OH:39])=[O:38].[CH3:1][C:2]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][N:15]([CH3:18])[CH2:14][CH2:13]2)=[C:8]2[C:3]=1[CH2:4][CH2:5][C@@H:6]([NH:19][C:20](=[O:33])[C:21]1[CH:26]=[CH:25][C:24]([N:27]3[CH2:32][CH2:31][O:30][CH2:29][CH2:28]3)=[CH:23][CH:22]=1)[CH2:7]2

参加物

5

反応物 3

HCID 1110Succinic AcidHCID 3283Diethyl EtherHCID 9846516AR-A000002

生成物 1

HCID 70029953HCID 70029953、化合物収率 34%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

(R)-N-[5-Methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide (100 mg, 0.22 mmol) was dissolved in tetrahydrofuran (2 mL) by heating and succinic acid (56 mg, 0.46 mmol), dissolved in tetrahydrofuran (2 mL), was added dropwise. Diethyl ether (4 mL) was added until the solution was cloudy. The solution was heated to reflux and set aside to cool. The solid was filtered to give 42 mg (34% yield) of a white solid that was stored in an exicator over blue gel: mp 150° C. (decom.).

後処理

  1. temperatureby heating
  2. additionwas added dropwise
  3. temperatureThe solution was heated
  4. temperatureto reflux
  5. temperatureto cool
  6. filtrationThe solid was filtered

出典と根拠

ORDレコード
ord-2860964122cc451087a925dcf0a4ba84
出典データセット
uspto-grants-2003_03
特許番号
US06534652B2

反応ノート

読み込み中…