Water → 2-Benzyloxy-5-(2-methoxymethoxyethyl)benzamide

To a stirred solution of 2-benzyloxy-5-(2-methoxymethoxyethyl)benzoic acid (900 mg) in tetrahydrofuran (25 ml) was added 1,1′-carbonyldiimidazole (507 mg) at room temperature, and the mixture was stirred for 1 hour. To the reaction mixture was added 28% ammonium hydroxide (3 ml), and the resulting mixture was stirred for 30 minutes at room temperature. Water was added to the reaction mixture, and the resulting mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. After the solvent was removed under reduced pressure, crystallization of the residue from hexane and diethyl ether (1/1) gave 2-benzyloxy-5-(2-methoxymethoxyethyl)benzamide (700 mg).

1. stirringthe resulting mixture was stirred for 30 minutes at room temperature
2. extractionthe resulting mixture was extracted with ethyl acetate
3. washThe extract was washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. customAfter the solvent was removed under reduced pressure, crystallization of the residue from hexane and diethyl ether (1/1)

ORDレコード

ord-5e66a412ccaf4bc9b0a727b0a7e73ec7

出典データセット

uspto-grants-2003_03

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06538152B1