M-Cresol → HCID 178433662、化合物
反応式
Cl.Cl.[CH3:3][C:4]1[NH:8][CH:7]=[N:6][C:5]=1[CH2:9][CH2:10][NH2:11].[OH-].[Na+].C1(C)C=CC=C(O[C:21](=[NH:25])[NH:22][C:23]#[N:24])C=1.C1C(O)=CC=CC=1C>C(O)(C)C>[C:21]([NH:22][C:23]([NH:11][CH2:10][CH2:9][C:5]1[N:6]=[CH:7][NH:8][C:4]=1[CH3:3])=[NH:24])#[N:25]参加物
6
実験手順
4.94 g. (0.249 mole) 5-methyl-4-(2-aminoethyl) imidazole dihydrochloride is converted to the free base with NaOH. The free base is combined with 4.36 g. (0.0249 mole) of O-m-tolyl-N-cyanoisourea in 63 ml. isopropanol. This mixture is refluxed for one hour. The mixture is then cooled to room temperature, filtered to remove insoluble material, and the solvent is evaporated to obtain a cloudy oil of the product mixed with m-cresol.
後処理
- temperatureThis mixture is refluxed for one hour
- filtrationfiltered
- customto remove insoluble material
- customthe solvent is evaporated
- customto obtain a cloudy oil of the product
出典と根拠
- ORDレコード
- ord-e42112a5cade4e968931eb96eaf9b353
- 出典データセット
- uspto-grants-1979_09
- 特許番号
- US04166860
反応ノート
読み込み中…