Ethanolamine → HCID 85986168、化合物

HRID 1863991ノート

反応式

HRID 1863991 の反応式
Cl.[Cl:2][C:3]1[C:8]([CH2:9]Cl)=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1.[CH2:17]([CH2:19][NH2:20])[OH:18].O>O1CCCC1>[Cl:2][C:3]1[C:8]([CH2:9][NH:20][CH2:19][CH2:17][OH:18])=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][N:4]=1

参加物

5

反応物 3

HCID 700EthanolamineHCID 962WaterHCID 23089937737786-09-3

生成物 1

HCID 85986168HCID 85986168、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a suspension of 2-chloro-3-(chloromethyl)-4-phenylpyridine hydrochloride (12.6 g) obtained in Reference Example 2C in tetrahydrofuran (150 ml) was added ethanolamine (14 ml), and the mixture was heated under reflux for 6 hrs. After cooling the reaction solution, water was added and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and saturated brine, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (13.4 g) as a colorless oil.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 6 hrs
  3. additionwas added
  4. extractionthe mixture was extracted with ethyl acetate
  5. washThe organic layer was washed successively with water and saturated brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-c477ce7a5bbd40128e0f1fee1f336cb0
出典データセット
uspto-grants-2009_12
特許番号
US07625887B2

反応ノート

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