Ammonium formate → HCID 68749290、化合物
反応式
[CH3:1][Si:2]([CH3:16])([CH3:15])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7].C([O-])=O.[NH4+:20]>[Pd].O.CO>[CH3:1][Si:2]([CH3:16])([CH3:15])[CH2:3][CH2:4][O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH2:20])[CH2:10][CH2:9]1)=[O:7]参加物
6
実験手順
A slurry of 10% palladium on carbon (200 mg) in water was added to 4-oxo-piperidine-1-carboxylic acid-2-trimethylsilanyl-ethyl ester (2.42 g, 10 mmol) in 100 mL of methanol. Ammonium formate (6.0 g, 95 mmol) in water was added dropwise, and the mixture stirred vigorously overnight. The mixture was filtered and the filtrate concentrated in vacuo to leave the crude product. Chromatography (elution with methanol-dichloromethane) provided 0.98 g of product.
後処理
- filtrationThe mixture was filtered
- concentrationthe filtrate concentrated in vacuo
- customto leave the crude product
- washChromatography (elution with methanol-dichloromethane)
出典と根拠
- ORDレコード
- ord-e09efe30857045cbbddb93b978dbd682
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07625889B2
反応ノート
読み込み中…