Methanol → 7-Methoxyquinoline-3-carboxylic acid
反応式
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]([O:15]CC)=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1.CO.[OH-].[Na+]>C1COCC1>[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([C:13]([OH:15])=[O:14])[CH:9]=[N:10]2)=[CH:5][CH:4]=1参加物
5
実験手順
To a solution of the intermediate from step C (399 mg, mmol) in THF (6 mL) was added methanol (1 mL) followed by NaOH (5N, 1.5 mL). After stirring at room temperature for 18 hours the reaction was concentrated in vacuo. The residue was acidified with 1N HCl (10 mL). The solution was concentrated in vacuo and azeotroped with toluene (4×). This material was used in the next step without any further purification.
後処理
- concentrationwas concentrated in vacuo
- concentrationThe solution was concentrated in vacuo
- customazeotroped with toluene (4×)
- customThis material was used in the next step without any further purification
出典と根拠
- ORDレコード
- ord-22146aec56cb4f5692070cd8f65af8cd
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07625938B2
反応ノート
読み込み中…