Dichloroacetic Acid → HCID 54724182、化合物

HRID 1867023ノート

反応式

HRID 1867023 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]1=[O:13].[I:17]N1C(=O)CCC1=O.ClC(Cl)C(O)=O>C(#N)C>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][N:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([I:17])[C:7]1=[O:13]

参加物

5

反応物 3

HCID 6597Dichloroacetic AcidHCID 120273N-IodosuccinimideHCID 54724162HCID 54724162、化合物

生成物 1

HCID 54724182HCID 54724182、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a mixture of 1-(3-fluorobenzyl)-4-hydroxypyridin-2(1H)-one (1.1 g, 5 mmol) in acetonitrile (15 mL) was added N-iodosuccinimide (1.1 g, 5.5 mmol) along with a ca. amount of dichloroacetic acid (0.1 mL). The reaction mixture stirred at room temperature for 1 hour under nitrogen. The mixture was chilled in an ice bath and filtered cold with fresh MeCl2. The beige solid was dried to afford the desired iodinated intermediate (1.21 g, 69%). ES-LRMS m/z 346.

後処理

  1. temperatureThe mixture was chilled in an ice bath
  2. filtrationfiltered cold with fresh MeCl2
  3. customThe beige solid was dried
  4. customto afford the

出典と根拠

ORDレコード
ord-dce047879a5148b7bccca72715b1a0db
出典データセット
uspto-grants-2009_12
特許番号
US07629363B2

反応ノート

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