Methyl iodide → 2-(4-Chloro-2-iodophenyl)propanenitrile
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[C:4]([I:11])[CH:3]=1.[CH3:12]C(C)([O-])C.[Na+].CI>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]#[N:10])=[C:4]([I:11])[CH:3]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
2-(4-Chloro-2-iodophenyl)acetonitrile (1.070 g, 3.9 mmol) was dissolved in THF (50 mL) and cooled to 0° C. Sodium tert-butoxide (0.74 g, 7.7 mmol) was added, and the solution was stirred for 10 minutes (the reaction color changed from colorless to orange.) MeI (0.24 mL, 3.9 mmol) was then added dropwise as a solution in THF (10 mL). The reaction was complete in ten minutes as determined by TLC. The crude residue was purified by silica flash chromatography using 0-15% EtOAc/hexanes. MS m/e=292 (M+H)+.
後処理
- waitThe reaction was complete in ten minutes
- customThe crude residue was purified by silica flash chromatography
出典と根拠
- ORDレコード
- ord-0b2f91b9490e4bfaa14229b14bba1c78
- 出典データセット
- uspto-grants-2009_12
- 特許番号
- US07635715B2
反応ノート
読み込み中…