3-Ethynylaniline hydrochloride → (6-Carbomethoxyquinazolin-4-yl)-(3-ethynylphenyl)-amine Hydrochloride

HRID 1869075

反応式

HRID 1869075 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]([O:14][CH3:15])=[O:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.Cl.[C:17]([C:19]1[CH:20]=[C:21]([CH:23]=[CH:24][CH:25]=1)[NH2:22])#[CH:18]>C(O)(C)(C)C.C(O)(C)C>[ClH:1].[C:12]([C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][N:3]=[C:2]2[NH:22][C:21]1[CH:23]=[CH:24][CH:25]=[C:19]([C:17]#[CH:18])[CH:20]=1)([O:14][CH3:15])=[O:13]

参加物

5

反応物 2

HCID 189250233-Ethynylaniline hydrochlorideHCID 18925080Methyl 4-chloroquinazoline-6-carboxylate

生成物 1

HCID 18925071(6-Carbomethoxyquinazolin-4-yl)-(3-ethynylphenyl)-amine Hydrochloride

試薬・触媒・溶媒 2

HCID 3776Isopropanol溶媒HCID 6386tert-Butanol溶媒

実験手順

4-Chloro-6-carbomethoxyquinazoline (100 mg, 0.450 mmol) and 3-ethynylaniline hydrochloride (53.4 mg, 0.456 mmol) were refluxed in 2 mL of tert-butyl alcohol for 2 hours, cooled, diluted with 2 mL of isopropyl alcohol and filtered to afford solid title product which was washed with 10 mL of diethyl ether and dried, in vacuo, at 70° C., 122 mg (80%); mp 232°-233° C. (dec).

後処理

  1. temperaturecooled
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-e3575eab7f0144ebb14c6edee87de436
出典データセット
uspto-grants-2009_12
特許番号
USRE041065E1

関連ノート

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