4-Methoxybenzenesulfonyl chloride → 5-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline

HRID 18694

反応式

HRID 18694 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[NH:7][CH2:6][CH2:5]2.[CH3:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-:13])=[O:12])[CH:10]=1)[N:7]([S:22]([C:19]1[CH:18]=[CH:17][C:16]([O:15][CH3:14])=[CH:21][CH:20]=1)(=[O:24])=[O:23])[CH2:6][CH2:5]2

参加物

4

反応物 2

HCID 74014-Methoxybenzenesulfonyl chlorideHCID 30189115-Bromo-7-nitroindoline

生成物 1

HCID 686126655-Bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The preparation involved a straightforward reaction sequence with high yields (overall 48-56% in three or four steps). The commercially available 5-bromo-7-nitroindoline (16) was reacted with the 4-methoxybenzenesulfonyl chloride in pyridine to afford the 5-bromo-1-(4-methoxybenzenesulfonyl)-7-nitroindoline (17).

後処理

  1. customwith high yields (overall 48-56% in three or four steps)

出典と根拠

ORDレコード
ord-84ed2333241244709d8e914e59951045
出典データセット
uspto-grants-2010_06
特許番号
US07741495B2

関連ノート

読み込み中…