Methyl iodide → (cis)-4-(3,4-Dimethoxyphenyl)-2-methyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

HRID 1871366ノート

反応式

HRID 1871366 の反応式
[H-].[Na+].[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C@H:22]3[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]3)[C:16](=[O:23])[NH:15][N:14]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12].I[CH3:25]>CN(C)C=O>[CH3:3][O:4][C:5]1[CH:6]=[C:7]([C:13]2[C@H:22]3[C@H:17]([CH2:18][CH2:19][CH2:20][CH2:21]3)[C:16](=[O:23])[N:15]([CH3:25])[N:14]=2)[CH:8]=[CH:9][C:10]=1[O:11][CH3:12]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 10913208(cis)-4-(3,4-Dimethoxyphenyl)-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

生成物 1

HCID 70003942(cis)-4-(3,4-Dimethoxyphenyl)-2-methyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6 mmol of a 60% suspension of sodium hydride in mineral oil was added to a suspension of 5 mmol of compound 1 in about 40 ml of dimethylformamide, under a flow of nitrogen at room temperature. After stirring this mixture for 30 minutes, 7 mmol of iodomethane was added and the resulting mixture was stirred for another 4 hours, after which the solvent was evaporated. The residue was partitioned between ethyl acetate and water, the organic layer was dried over magnesium sulfate and evaporated. The residue was purified by chromatography (dichloromethane). Crystallized from petroleum ether (60-95° C.). M.p. 110-112° C.

後処理

  1. stirringthe resulting mixture was stirred for another 4 hours
  2. customafter which the solvent was evaporated
  3. customThe residue was partitioned between ethyl acetate and water
  4. dry with materialthe organic layer was dried over magnesium sulfate
  5. customevaporated
  6. customThe residue was purified by chromatography (dichloromethane)
  7. customCrystallized from petroleum ether (60-95° C.)

出典と根拠

ORDレコード
ord-1e050df5a8f64e808385a028b55c4ce4
出典データセット
uspto-grants-2000_08
特許番号
US06103718

反応ノート

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