反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])[CH:12]=[CH:13][C:14]=2[CH3:15])=[CH:4][CH:3]=1.[N:24]([C:27](OCC)=O)=C=S.[Cl-].O[NH3+].C([N:38](CC)C(C)C)(C)C>CO.C(O)C.CS(C)=O>[NH2:38][C:27]1[N:1]=[C:2]2[CH:3]=[CH:4][C:5]([O:8][C:9]3[CH:10]=[C:11]([NH:16][C:17](=[O:23])[O:18][C:19]([CH3:20])([CH3:22])[CH3:21])[CH:12]=[CH:13][C:14]=3[CH3:15])=[CH:6][N:7]2[N:24]=1参加物
8
反応物 4
生成物 1
試薬・触媒・溶媒 3
実験手順
In the same manner as in Example 17-1 and using tert-butyl {3-[(6-aminopyridin-3-yl)oxy]-4-methylphenyl}carbamate (1.69 g, 5.35 mmol), DMSO (5 mL), ethyl isothiocyanatoformate (843 mg, 6.42 mmol), ethanol (20 mL), methanol (20 mL), hydroxylammonium chloride (2.43 g, 35.0 mmol) and N,N-diisopropylethylamine (4.35 mL, 25.0 mmol) as starting materials, the title compound (1.55 g, 87%) was obtained as a white solid.
出典と根拠
- ORDレコード
- ord-4db9f563c2f542eb90a1e5ba9c8f4e56
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304557B2
関連ノート
読み込み中…