反応式
[NH2:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:21])([CH3:20])[CH3:19])[CH:12]=[CH:13][CH:14]=2)=[CH:4][CH:3]=1.[N:23]([C:26](OCC)=O)=C=S.[Cl-].O[NH3+].C([N:37](CC)C(C)C)(C)C>CO.C(O)C.CS(C)=O>[NH2:37][C:26]1[N:1]=[C:2]2[CH:3]=[CH:4][C:5]([O:8][C:9]3[CH:10]=[C:11]([NH:15][C:16](=[O:22])[O:17][C:18]([CH3:19])([CH3:21])[CH3:20])[CH:12]=[CH:13][CH:14]=3)=[CH:6][N:7]2[N:23]=1参加物
8
反応物 4
生成物 1
試薬・触媒・溶媒 3
実験手順
In the same manner as in Example 17-1 and using tert-butyl {3-[(6-aminopyridin-3-yl)oxy]phenyl}carbamate (15.0 g, 49.8 mmol), ethyl isothiocyanatoformate (7.18 g, 54.8 mmol), DMSO (50 mL), hydroxylammonium chloride (11.8 g, 170 mmol), N,N-diisopropylethylamine (21.2 mL, 122 mmol), ethanol (70 mL) and methanol (70 mL) as starting materials, the title compound (10.5 g, 94%) was obtained as a white solid.
出典と根拠
- ORDレコード
- ord-67168c839fcc4a498f73b6428604e2d4
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304557B2
関連ノート
読み込み中…