反応式
[CH3:1][C:2]1[S:3][C:4]([CH3:10])=[CH:5][C:6]=1[C:7]([OH:9])=O.O1CCCC1.S(Cl)(Cl)=O.[NH2:20][C:21]1[CH:22]=[C:23]([CH:40]=[CH:41][C:42]=1[CH3:43])[O:24][C:25]1[CH:26]=[CH:27][C:28]2[N:29]([N:31]=[C:32]([NH:34][C:35]([CH:37]3[CH2:39][CH2:38]3)=[O:36])[N:33]=2)[CH:30]=1>CN(C)C=O.CN(C)C(=O)C>[CH:37]1([C:35]([NH:34][C:32]2[N:33]=[C:28]3[CH:27]=[CH:26][C:25]([O:24][C:23]4[CH:40]=[CH:41][C:42]([CH3:43])=[C:21]([NH:20][C:7]([C:6]5[CH:5]=[C:4]([CH3:10])[S:3][C:2]=5[CH3:1])=[O:9])[CH:22]=4)=[CH:30][N:29]3[N:31]=2)=[O:36])[CH2:38][CH2:39]1参加物
7
反応物 4
生成物 1
試薬・触媒・溶媒 2
実験手順
In the same manner as in Example 55 and using 2,5-dimethylthiophene-3-carboxylic acid (71.0 mg, 0.454 mmol), tetrahydrofuran (5 mL), thionyl chloride (77.0 μL, 0.888 mmol), N,N-dimethylformamide (2 drops), N-[6-(3-amino-4-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide (129 mg, 0.399 mmol) and N,N-dimethylacetamide (6 mL) as starting materials, the title compound (137 mg, 74%) was obtained as a white solid.
出典と根拠
- ORDレコード
- ord-0ddedd9411fe43ce97d17be17a66e861
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08304557B2
関連ノート
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