Sodium Carbonate → HCID 57448056、化合物

HRID 1879062ノート

反応式

HRID 1879062 の反応式
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])=[O:4].[BH4-].[Na+].C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[F:19][C:2]([F:1])([F:18])[CH:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]2)[C:6]=1[F:17])[OH:4]

参加物

5

反応物 3

HCID 10340Sodium CarbonateHCID 4311764Sodium borohydrideHCID 67532664HCID 67532664、化合物

生成物 1

HCID 57448056HCID 57448056、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,2,2-trifluoro-1-(2-fluoro-3-piperidin-4-ylphenyl)ethanone (0.045 g, 0.16 mmol) was dissolved in ethanol (10 ml) and sodium borohydride (0.026 g, 0.064 mmol) was added. The resulting mixture was stirred for 24 h, after which aqueous sodium carbonate (10%, 20 ml) was added. The aqueous phase was extracted with ethylacetate (3×20 ml) and the combined organic phases was dried (MgSO4), filtered and evaporated to dryness. Yield: 0.03 g. MS m/z (rel. intensity, 70 eV) 277 (M+, 87), 276 (69), 178 (14), 103 (19), 56 (bp).

後処理

  1. extractionThe aqueous phase was extracted with ethylacetate (3×20 ml)
  2. dry with materialthe combined organic phases was dried (MgSO4)
  3. filtrationfiltered
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-604700d3ce15492ba859edc2b48ccb50
出典データセット
uspto-grants-2012_11
特許番号
US08314126B2

反応ノート

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