Methyl iodide → Methyl 1-methyl-1H-indazole-5-carboxylate
反応式
[H-].[Na+].[NH:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=2)[CH:5]=[N:4]1.I[CH3:17]>CN(C=O)C>[CH3:17][N:3]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:10]=2)[CH:5]=[N:4]1参加物
5
実験手順
To a stirred suspension of 60% NaH oil dispersion (87 mg, 2.2 mmol) in DMF (4 mL) was added methyl 1H-indazole-5-carboxylate (264 mg, 1.50 mmol). The mixture was stirred at room temperature for 1 hour before the dropwise addition of iodomethane (0.11 mL, 1.8 mmol). The mixture was stirred at room temperature for 2 hours, concentrated and the residue was purified by Biotage chromatography (40S column, 15% acetone/heptane) to afford methyl 1-methyl-1H-indazole-5-carboxylate (107 mg, 38%).
後処理
- concentrationconcentrated
- customthe residue was purified by Biotage chromatography (40S column, 15% acetone/heptane)
出典と根拠
- ORDレコード
- ord-5d58199b1e18474facd69ca6b3e136c3
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318762B2
反応ノート
読み込み中…