Lithium Hydroxide → 1-Methyl-1H-indazole-5-carboxylic acid
反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([O:13]C)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[N:3]1.[Li+].[OH-].OS([O-])(=O)=O.[K+]>CO.O.O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([OH:13])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[N:3]1参加物
6
反応条件
- 温度
- 40 °C
実験手順
To a solution of methyl 1-methyl-1H-indazole-5-carboxylate (107 mg, 0.56 mmol) in methanol/water (V:V 1:1, 4 mL) was added LiOH (48 mg). The solution was heated at 40° C. for 3 hours before cooling to room temperature. The mixture was diluted with water and acidified to pH 3.5-4 with KHSO4. Solids precipitated and were isolated by filtration and dried under vacuum to afford the title compound as a yellow solid (70 mg, 71%).
後処理
- temperaturebefore cooling to room temperature
- customSolids precipitated
- customwere isolated by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-ff5c23545483430f88175547e541a4d5
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318762B2
反応ノート
読み込み中…