Acetonitrile → HCID 59570299、化合物

HRID 1880762ノート

反応式

HRID 1880762 の反応式
[C:1](#[N:3])C.[F:4][C:5]([F:23])([F:22])[CH:6]([C:15]1[CH:20]=[CH:19][N+:18]([O-])=[CH:17][CH:16]=1)[O:7][Si:8]([CH2:13][CH3:14])([CH2:11][CH3:12])[CH2:9][CH3:10].C[Si](C#N)(C)C>C(N(CC)CC)C>[F:4][C:5]([F:23])([F:22])[CH:6]([C:15]1[CH:20]=[CH:19][N:18]=[C:17]([C:1]#[N:3])[CH:16]=1)[O:7][Si:8]([CH2:13][CH3:14])([CH2:11][CH3:12])[CH2:9][CH3:10]

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 82115Trimethylsilyl cyanideHCID 595703784-[2,2,2-trifluoro-1-(triethylsilyloxy)ethyl]pyridine N-oxide

生成物 1

HCID 59570299HCID 59570299、化合物

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
90 °C

実験手順

To 40 ml of acetonitrile were added 5 g of 4-[2,2,2-trifluoro-1-(triethylsilyloxy)ethyl]pyridine N-oxide, 5.26 ml of triethylamine, and 5.62 g of trimethylsilyl cyanide, and the mixture was stirred at 90° C. for 20 hours. Thereafter, the reaction solution was allowed to cool to room temperature, and concentrated. The residue was subjected to silica gel column chromatography to obtain 3 g of 4-[2,2,2-trifluoro-1-(triethylsilyloxy)ethyl]pyridine-2-carbonitrile.

後処理

  1. temperatureto cool to room temperature
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-f4dc8124fc2a43a18c4295c4153fa197
出典データセット
uspto-grants-2012_11
特許番号
US08318776B2

反応ノート

読み込み中…