4-[1-(Trifluoromethyl)ethenyl]pyridine → 4-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine

HRID 1880771

反応式

HRID 1880771 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)=[CH2:4].[H][H]>[Pd].C(OCC)(=O)C>[F:12][C:2]([F:1])([F:11])[CH:3]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)[CH3:4]

参加物

5

反応物 2

HCID 595703554-[1-(Trifluoromethyl)ethenyl]pyridineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 595703374-(2,2,2-Trifluoro-1-methyl-ethyl)pyridine収率 85.7%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To 20 ml of ethyl acetate were added 1.5 g of 4-[1-(trifluoromethyl)ethenyl]pyridine and 0.15 g of 10% Pd/C, and the mixture was stirred under the hydrogen atmosphere for 7 hours. The mixture was filtered, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography to obtain 1.3 g of 4-(2,2,2-trifluoro-1-methyl-ethyl)pyridine.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-3931ff0361f24cb786007c5b926220fa
出典データセット
uspto-grants-2012_11
特許番号
US08318776B2

関連ノート

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