Diethyl Ether → Ethyl 2-(Benzylsulfanyl)acetate

HRID 18808

反応式

HRID 18808 の反応式
[CH2:1]([SH:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18].CCOCC>CN(C=O)C>[CH2:20]([O:19][C:17](=[O:18])[CH2:16][S:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:21]

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 7509Benzyl mercaptanHCID 7748Ethyl bromoacetateHCID 11430Potassium Carbonate

生成物 1

HCID 3344750Ethyl 2-(Benzylsulfanyl)acetate収率 49.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of benzyl mercaptan (1.18 mL, 10.0 mmol) in DMF (20 mL) is added potassium carbonate (1.51 g, 10.9 mmol) and ethyl bromoacetate (1.17 mL, 10.6 mmol), and the mixture is stirred at RT for 25 min. Et2O is added, and the mixture is washed with water, brine, then dried (MgSO4), and filtered. The filtrate is evaporated, and the residue is vacuum distilled (130-140° C.) to give 1.05 g of the product 402.

後処理

  1. washthe mixture is washed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. customThe filtrate is evaporated
  5. distillationdistilled (130-140° C.)

出典と根拠

ORDレコード
ord-b23c6536424c4e7d8c34c22f26f46f35
出典データセット
uspto-grants-2010_06
特許番号
US07741493B2

関連ノート

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