Water → 4,5-Dimethoxyphthalic acid

HRID 1881207

反応式

HRID 1881207 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[O:7][CH2:6]2.[OH-:15].[Na+].[O-][Mn](=O)(=O)=O.[K+].[OH2:23]>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:6]([OH:23])=[O:15])[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8]([OH:7])=[O:14]

参加物

5

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 2304605,6-Dimethoxy-3H-isobenzofuran-1-oneHCID 516875Potassium Permanganate

生成物 1

HCID 2909884,5-Dimethoxyphthalic acid

実験手順

To a mixture of 5,6-dimethoxy-3H-isobenzofuran-1-one (4.5 g) and 7% aqueous NaOH (47 ml) was added KMnO4 (4.0 g) diluted in water (125 ml). The mixture was stirred at room temperature for 4 days. Insoluble material was removed by filtration. The filtrate was cooled with ice-water bath and acidified with concentrated HCl. The acidic solution was extracted three times with ethyl acetate (300 ml). The combined organic layers were dried over anhydrous Na2SO4 and evaporated.

後処理

  1. customInsoluble material was removed by filtration
  2. temperatureThe filtrate was cooled with ice-water bath
  3. extractionThe acidic solution was extracted three times with ethyl acetate (300 ml)
  4. dry with materialThe combined organic layers were dried over anhydrous Na2SO4
  5. customevaporated

出典と根拠

ORDレコード
ord-cb3ce5ebad0a4a1685bfee8cd89ad000
出典データセット
uspto-grants-2012_11
特許番号
US08318785B2

関連ノート

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