Sodium Hydroxide → 5-[Bis(methyloxy)methyl]-3-bromo-2-methylpyridine 1-oxide
反応式
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[CH3:12][O:13][CH:14]([O:23][CH3:24])[C:15]1[CH:16]=[C:17]([Br:22])[C:18]([CH3:21])=[N:19][CH:20]=1.C([O-])(O)=O.[Na+].[OH-].[Na+]>C(Cl)Cl>[CH3:24][O:23][CH:14]([O:13][CH3:12])[C:15]1[CH:16]=[C:17]([Br:22])[C:18]([CH3:21])=[N+:19]([O-:9])[CH:20]=1参加物
6
実験手順
m-CPBA (242 mg, 1.052 mmol) was added to a suspension of 5-[bis(methyloxy)methyl]-3-bromo-2-methylpyridine (129.5 mg, 0.526 mmol) and NaHCO3 (133 mg, 1.579 mmol) in DCM (5 ml). The mixture was stirred at room temperature overnight. To the resulting white suspension was added DCM and 1N NaOH. The organic phase was extracted twice,
後処理
- extractionThe organic phase was extracted twice
出典と根拠
- ORDレコード
- ord-9de1d027737c4d9fa3cd4959679e90a0
- 出典データセット
- uspto-grants-2012_11
- 特許番号
- US08318940B2
反応ノート
読み込み中…