Sulfamethazine → 4-(Benzhydrylamino)-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide

HRID 1884824

反応式

HRID 1884824 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH3:19])[N:5]=[C:6]([NH:8][S:9]([C:12]2[CH:13]=[CH:14][C:15]([NH2:18])=[CH:16][CH:17]=2)(=[O:11])=[O:10])[N:7]=1.[C:20]1([CH:26]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)Cl)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>N1C=CC=CC=1>[CH:26]([NH:18][C:15]1[CH:16]=[CH:17][C:12]([S:9]([NH:8][C:6]2[N:5]=[C:4]([CH3:19])[CH:3]=[C:2]([CH3:1])[N:7]=2)(=[O:11])=[O:10])=[CH:13][CH:14]=1)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

参加物

4

反応物 2

HCID 5327SulfamethazineHCID 7035Chlorodiphenylmethane

生成物 1

HCID 235049124-(Benzhydrylamino)-N-(4,6-dimethylpyrimidin-2-yl)-benzenesulfonamide収率 8%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Sulfamethazine (105 mg, 0.38 mmol) and diphenylchloromethane (77 μl, 0.38 mmol) were dissolved in 3 ml pyridine. Solution was stirred and refluxed overnight. The reaction mixture was evaporated to dryness and dissolved to 1 M NaOH. Product was precipitated with 1 M acetic acid. Precipitation cycle was repeated for three times to give white crystals of the title compound with a yield of 8%. MS (ESI+): m/z 467(M+Na)+, 445 (M+H)+.

後処理

  1. temperaturerefluxed overnight
  2. customThe reaction mixture was evaporated to dryness
  3. dissolutiondissolved to 1 M NaOH
  4. customProduct was precipitated with 1 M acetic acid
  5. customPrecipitation cycle

出典と根拠

ORDレコード
ord-6d8d7276116f4d48adbb4f1f7e49ce4e
出典データセット
uspto-grants-2004_07
特許番号
US06767909B2

関連ノート

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