Sodium Iodide → HCID 67119908、化合物

HRID 1888086ノート

反応式

HRID 1888086 の反応式
[Cl-:1].[Ce+3].[Cl-].[Cl-].[I-].[Na+].Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1)=[O:10].[CH2:23]([N:30]1[CH2:35][CH2:34][C:33](=[O:36])[CH2:32][CH2:31]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCCC1>[ClH:1].[CH2:23]([N:30]1[CH2:35][CH2:34][C:33]([CH2:8][C:9](=[O:10])[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)([OH:36])[CH2:32][CH2:31]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 192201-Benzyl-4-piperidoneHCID 24636Cerium(III) chlorideHCID 27953572-Bromo-1-(4-morpholinophenyl)ethanone

生成物 1

HCID 67119908HCID 67119908、化合物収率 40%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 1.07 g (4.0 mmol) of 2-bromo-1-(4-morpholinophenyl)ethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone into 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three to obtain 0.69 g of a white crystal, with yield of 34.3%.

後処理

  1. customto form a suspension
  2. additionthe solution is added dropwise to the above suspension

出典と根拠

ORDレコード
ord-7be1c0ae7f014ef6994d40a10ad680e3
出典データセット
uspto-grants-2013_08
特許番号
US08501778B2

反応ノート

読み込み中…