Sodium hydride → 5-(3-Fluorophenyl)morpholin-3-one

HRID 1890670ノート

反応式

HRID 1890670 の反応式
Cl[CH2:2][C:3]([NH:5][CH:6]([C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[CH2:7][OH:8])=[O:4].[H-].[Na+]>C1COCC1>[F:15][C:11]1[CH:10]=[C:9]([CH:6]2[NH:5][C:3](=[O:4])[CH2:2][O:8][CH2:7]2)[CH:14]=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 24758Sodium hydrideHCID 583359312-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide

生成物 1

HCID 583357985-(3-Fluorophenyl)morpholin-3-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

In step 2-3, a solution of 2-chloro-N-(1-(3-fluorophenyl)-2-hydroxyethyl)acetamide (5.5 g, 24 mmol) in THF (150 mL) was slowly added to a suspension of NaH (1.05 g, 26 mmol) in THF (600 mL) at 0° C. The heterogeneous solution was warmed to room temperature and stirred overnight. The reaction mixtures was quenched, concentrated and ethyl acetate was added to the residue. This solution was washed with water and brine and the organic phase was dried over MgSO4, filtered and concentrated to yield 5-(3-fluorophenyl)morpholin-3-one (2-3).

後処理

  1. customThe reaction mixtures
  2. customwas quenched
  3. concentrationconcentrated
  4. additionethyl acetate was added to the residue
  5. washThis solution was washed with water and brine
  6. dry with materialthe organic phase was dried over MgSO4
  7. filtrationfiltered
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-7eb810cdbd964038a132a13ba3a076e7
出典データセット
uspto-grants-2013_08
特許番号
US08507488B2

反応ノート

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