Tetrabutylammonium Fluoride → {3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol

HRID 1891239

反応式

HRID 1891239 の反応式
[Si]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([C:16]2[CH:17]=[CH:18][C:19]3[N:20]([C:22]([CH3:33])=[C:23]([C:25]4[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:26]=4[F:32])[N:24]=3)[CH:21]=2)[CH:13]=[CH:14][CH:15]=1)(C(C)(C)C)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[F:32][C:26]1[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:25]=1[C:23]1[N:24]=[C:19]2[CH:18]=[CH:17][C:16]([C:12]3[CH:11]=[C:10]([CH2:9][OH:8])[CH:15]=[CH:14][CH:13]=3)=[CH:21][N:20]2[C:22]=1[CH3:33]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 698104776-[3-(tert-Butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-a]pyridine

生成物 1

HCID 44233767{3-[2-(2,4-Difluorophenyl)-3-methylimidazo[1,2-alpha]pyridin-6-yl]phenyl}methanol収率 82.1%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

210 mg of 6-[3-(tert-butyldimethylsilanyloxymethyl)phenyl]-2-(2,4-difluorophenyl)-3-methylimidazo[1,2-α]pyridine in 5 ml of tetrahydrofuran are placed in a round-bottomed flask and 240 mg of tetrabutylammonium fluoride are added thereto. The mixture is stirred at ambient temperature for 48 h. The reaction mixture is then concentrated under reduced pressure. The residue is purified by silica gel chromatography, elution being carried out with a dichloromethane/methanol mixture. 130 mg of compound are obtained.

後処理

  1. concentrationThe reaction mixture is then concentrated under reduced pressure
  2. customThe residue is purified by silica gel chromatography, elution

出典と根拠

ORDレコード
ord-5127ccf1189a46d58465fd58b87a1788
出典データセット
uspto-grants-2013_08
特許番号
US08507520B2

関連ノート

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