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llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0

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反応

1,1'-Carbonyldiimidazole → N-(5-(2-(3-fluorophenyl)-2-methylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide

HRID 1893778

印刷プレビュー

反応式

HRID 1893778 の反応式

[F:1][C:2]1[CH:3]=[C:4]([C:8]2([CH3:23])[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([NH2:22])=[C:15]3[N:14]=2)[CH:5]=[CH:6][CH:7]=1.C1N=CN([C:29]([N:31]2[CH:35]=N[CH:33]=[CH:32]2)=[O:30])C=1.Cl.N1CC([OH:41])C1.CCN(C(C)C)C(C)C>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([C:8]2([CH3:23])[CH2:12][CH2:11][CH2:10][N:9]2[C:13]2[CH:18]=[CH:17][N:16]3[N:19]=[CH:20][C:21]([NH:22][C:29]([N:31]4[CH2:32][CH:33]([OH:41])[CH2:35]4)=[O:30])=[C:15]3[N:14]=2)[CH:5]=[CH:6][CH:7]=1

参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 682631,1'-Carbonyldiimidazole

HCID 81531Diisopropylethylamine

HCID 27592903-Hydroxyazetidine hydrochloride

HCID 67329558HCID 67329558、化合物

生成物 1

HCID 46188927N-(5-(2-(3-fluorophenyl)-2-methylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxyazetidine-1-carboxamide収率 55%

試薬・触媒・溶媒 1

HCID 6344

Dichloromethane

溶媒

実験手順

To a DCM (0.7 mL) solution of 5-(2-(3-fluorophenyl)-2-methylpyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-amine (25 mg, 0.08 mmol) was added CDI (20 mg, 0.12 mmol) at ambient temperature in one portion. After stirring one hour, azetidin-3-ol hydrochloride (20 mg, 0.12 mmol) was added in one portion, followed by addition of DIEA (0.028 mL, 0.16 mmol). The reaction was stirred for 30 minutes before it was concentrated and directly purified by reverse-phase column chromatography, eluting with 0 to 60% acetonitrile/water to yield the final product as a yellowish oil (18 mg, 55% yield). MS (apci) m/z=411.2 (M+H).

後処理

stirringThe reaction was stirred for 30 minutes before it
concentrationwas concentrated
customdirectly purified by reverse-phase column chromatography
washeluting with 0 to 60% acetonitrile/water

出典と根拠

ORDレコード: ord-abeeaee620b349ada7cbfbc30f94948e
出典データセット: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08513263B2

反応ノート

読み込み中…

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