Tetrahydrofuran → 2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

HRID 1895389ノート

反応式

HRID 1895389 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:15]1[CH:16]=[CH:17][C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 27420752-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester

生成物 1

HCID 181867402-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(Pyridin-4-ylamino)-thiazole-4-carboxylic acid (160 mg) was prepared according to General Procedure C using 2-(pyridin-4-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

後処理

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

出典と根拠

ORDレコード
ord-8a86c1ceea4c4d9b870e0da0a508ccf4
出典データセット
uspto-grants-2013_08
特許番号
US08513430B2

反応ノート

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