Tetrahydrofuran → 2-(3-Pyridinylamino)-4-thiazolecarboxylic acid

HRID 1895391ノート

反応式

HRID 1895391 の反応式
C([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[S:9][CH:10]=1)=[O:5])C.O1CCCC1.[OH-].[Na+]>CO>[N:14]1[CH:15]=[CH:16][CH:17]=[C:12]([NH:11][C:8]2[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:13]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 52903990HCID 52903990、化合物

生成物 1

HCID 529035842-(3-Pyridinylamino)-4-thiazolecarboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

2-(Pyridin-3-ylamino)-thiazole-4-carboxylic acid (165 mg) was prepared according to General Procedure C using 2-(pyridin-3-ylamino)-thiazole-4-carboxylic acid ethyl ester in methanol:tetrahydrofuran:2N NaOH (1:1:1, 1.5 mL). The solvents were evaporated and the compound was dried. The crude product was used without further purification.

後処理

  1. customThe solvents were evaporated
  2. customthe compound was dried
  3. customThe crude product was used without further purification

出典と根拠

ORDレコード
ord-95270e6983294e26ab93f029557e5b78
出典データセット
uspto-grants-2013_08
特許番号
US08513430B2

反応ノート

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